Choline ester formation in, and choline esterase activities of, tissues in vitro

Choline ester formation in, and choline esterase activities of, tissues in vitro.

Ccl. the Relative Choline-esterase Activities of Serum

FOLLOWING the discovery by Stedman et al. [1932] that the destruction of acetylcholine by blood serum was brought about by a specific enzyme, which they termed choline-esterase, Stedman et al. [1933] examined the blood sera from a number of species for the presence of this enzyme and compared the cholineesterase activities of these sera with their activities towards two other types of esters, n...

On The Physiological Significance of Choline Esterase *

During the last 20 years evidence has accumulated, mainly from the work of 0. Loewi, Dale, Cannon and their co-workers, supporting the view that the action of sympathetic and parasympathetic nerves on the effector organ occurs by virtue of chemical mediation. It is generally believed that adrenaline, or a related substance, sympathin, is the transmitter substance at sympathetic nerve endings, w...

Studies on the Specificity of Choline Esterase

The present investigation was undertaken to determine the relation between the structure of various substrates and the action of serum choline esterase upon them. The comparison of activities with different esters should take into account two factors : the hydrolytic velocities compared should be linear functions of time, and these velocities should be independent of substrate concentration. Th...

Cccv. the Purification of Choline-esterase

ALTHOUGH it was previously known from pharmacological experiments, quoted in our earlier papers, that certain body fluids brought about the enzymic decomposition of small amounts of acetylcholine, the first demonstration of the existence of a specific enzyme which catalyses the hydrolysis of this ester, as well as of other esters of choline, was that of Stedman et al. [1932] who termed the enzy...